(-)-Epigallocatechin Gallate (EGCG)
(-)-表沒食子兒茶素沒食子酸酯
產品信息
產品名稱 | 產品編號 | CAS NO. | 規格 | 價格（元） |
(-)-Epigallocatechin Gallate (EGCG) | MZ3651-100MG | 989-51-5 | 100mg | 498 |
(-)-Epigallocatechin Gallate (EGCG) | MZ3651-500MG | 989-51-5 | 500mg | 1988 |
產品描述
(-)-表沒食子兒茶素沒食子酸酯（(-)-Epigallocatechin Gallate, EGCG），CAS NO. 989-51-5，是從綠茶中提取純化的一種成分，是兒茶素類化合物中zui有效的活性成分，具有zui強的抗氧化、抗癌、抗突變和抗血管生成活性，已被用于多種腫瘤包括肝癌、胃癌、皮膚癌、乳xian癌和結腸癌等的化學預防研究中，也對許多病毒包括HCV、HIV-1、HSV-1、HSV-2、腺病毒等有抑制作用。EGCG屬于一種天然的多酚黃酮類抗生素，能夠抑制端粒酶（omerase）和DNA甲基轉移酶（DNA methyltransferase），阻止EGF受體和HER-2受體的激活，也能抑制脂肪酸合成酶和谷氨酸脫氫酶的活性。是一種β-分泌酶抑制劑（IC50=1.6μM），能抑制淀粉樣蛋白的組裝，抑制由蛋白如Aβ，α-突觸核蛋白和亨廷頓蛋白介導的淀粉樣纖維的形成。能抑制細胞生長和選擇性誘導A431和人胰腺癌細胞的凋亡。也是DNMT1抑制劑。
產品特性
CAS NO：989-51-5
化學名：3,4,5-Trihydroxybenzoic acid (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1- benzopyran-3-yl ester
同義名：Epigallocatechin gallate表沒食子兒茶素沒食子酸酯；Tea catechin兒茶素；NVP-XAA723；Teavigo；
分子式：C22H18O11
分子量：458.37 g/mol
純度：≥98% (HPLC)
外觀：類白色至白色粉末
溶解性：溶于H2O（5 mg/ml），DMSO（20 mg/ml），無水乙醇（45 mg/ml）
化學結構：
使用方法【源自文獻，僅作參考】
文獻1，Rasheed NO et al. Nephro-toxic effects of intraperitoneally injected EGCG in diabetic mice: involvement of oxidative stress, inflammation and apoptosis. Sci Rep. 2017 Jan 18;7:40617. PMID: 28098182 體內研究： 動物模型（Animal Model）：Male Swiss albino mice weighing 25–30?g 藥物配制（Preparation）：Teavigo, a highly purified extract containing 94% EGCG, dissolved in saline 注射劑量（Dosages）：Mice were randomly divided into 4 groups 8 mice each except group 4 in which 15 mice were used: Group 1 received saline served as normal control. Group 2 received a single dose of STZ (150?mg/kg, i.p) used as diabetic control. Group 3 received EGCG (100?mg/kg, i.p) dissolved in saline for 4 days. Group 4 received STZ as in group 2 then the diabetic animals were injected after 48?hrs with EGCG as in group 3. After 48?hrs of STZ injection, animals with blood glucose level ≥200?mg/dl were selected as diabetic animals. 給藥途徑（Administration）：Intraperitoneal (i.p.) injection |
文獻2，Pan C et al. NRF2 Plays a Critical Role in Both Self and EGCG Protection against Diabetic Testicular Damage. Oxid Med Cell Longev. 2017;2017:3172692. PMID: 28698767 體內研究： 動物模型（Animal Model）：Eight-week-old male mice that was successfully induced as diabetic mice. 藥物配制（Preparation）：EGCG dissolved in normal saline 注射劑量（Dosages）：The diabetic mice and age-matched controls were treated daily by subcutaneously injected EGCG (100?mg/kg ≥98%, dissolved in normal saline) or normal saline daily, for a total period of 24 weeks. Blood glucose was recorded on days 0, 28, 56, 84, 112, 140, and 168, after diabetes onset. 給藥途徑（Administration）：Subcutaneous (s.c.) injection |
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EGCG 兒茶素類抗氧化劑 信號轉導研究
EGCG 兒茶素類抗氧化劑 信號轉導研究
