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背景資料
Glucagon is an important hormone involved in carbohydrate metabolism. The hormone is synthesized and secreted from alpha cells (?-cells) of the islets of Langerhans, which are located in the endocrine portion of the pancreas. Glucagon is released when the glucose level in the blood is low (hypoglycemia), causing the liver to convert stored glycogen into glucose and release it into the bloodstream. The action of glucagon is thus opposite to that of insulin, which instructs the body’s cells to take in glucose from the blood in times of satiation.
Glucagon is beneficial for the culture of some cell types. It has been used in some biochemical regulation studies of glycogenolysis in hepatocytes. It has been also been found to induce DNA replication in primary cultures of adult rat hepatocytes when used in combinations with EGF and Insulin. Glucagon increases the blood glucose concentration by promoting rapid breakdown of liver glycogen, and also acts to relax smooth muscle such as the gastrointestinal tract.
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來源宿主
提供的【胰高血糖素】癸高血糖素Glucagon產品來源宿主,查看該產品說明書,或者在線咨詢我們。
溶解建議
提供的胰高血糖素產品為白色無菌凍干粉末,凍干粉里不含有其它添加劑。推薦使用無菌的1%的HCl溶液溶解到0.1-1mg/ml濃度,便于后續稀釋。
保存建議
Glucagon although stable at room temperature for 3 weeks, should be stored desiccated below -18℃. Upon reconstitution Glucagon should be stored at 4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
其他
ProSpec 是一家全球著名細胞因子蛋白生產和研發的公司,具有20多年的生產經驗,專注于蛋白(重組及合成)生產研發。我們的核心產品包括:干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長因子、瘦素、干細胞因子、催乳素、表皮生長因子、胰島素樣生長因子、神經生長因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。 生產工藝和規模使其可以提供毫克到克級蛋白,價格優于同類公司。絕大部分產品是天然成熟型蛋白,而不含有標簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液,ProSpec-Tany絕大部分產品沒有添加保護劑或鹽,這就對工藝提出了更高的要求。同時,ProSpec-Tany絕大部分產品為凍干粉,因此易于運輸和保存。