產(chǎn)品新聞
背景資料
Human immunodeficiency virus （HIV） is a retrovirusthat can lead to a condition in which the immune systembegins to fail， leading to opportunistic infections. HIV primarily infects vital cells in the humanimmune systemsuch as helper T cells（specifically CD4+ T cells）， macrophagesand dendritic cells. HIV infection leads to low levels of CD4+ T cells through three main mechanisms: firstly， direct viral killing of infected cells； secondly， increased rates of apoptosisin infected cells； and thirdly， killing of infected CD4+ T cells by CD8 cytotoxic lymphocytesthat recognize infected cells. When CD4+ T cell numbers decline below a critical level， cell-mediated immunityis lost， and the body becomes progressively more susceptible to opportunistic infections. HIV was classified as a member of the genus Lentivirus， part of the family of Retroviridae. Lentiviruses have many common morphologies and biological properties. Many species are infected by lentiviruses， which are characteristically responsible for long-duration illnesses with a long incubation period. Lentiviruses are transmitted as single-stranded， positive-sense， enveloped RNA viruses. Upon entry of the target cell， the viral RNA genomeis converted to double-stranded DNAby a virally encoded reverse transcriptasethat is present in the virus particle. This viral DNA is then integrated into the cellular DNA by a virally encoded integraseso that the genome can be transcribed. Once the virus has infected the cell， two pathways are possible: either the virus becomes latentand the infected cell continues to function， or the virus becomes active and replicates， and a large number of virus particles are liberated that can then infect other cells.
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來源宿主
大腸桿菌中重組表達
溶解建議
提供的重組HIV-1 gp41包膜蛋白產(chǎn)品為無菌的無色透明溶液形式.該產(chǎn)品已溶解在含8M 尿素和20mM 巰基乙醇溶液.
保存建議
HIV-1 gp41 protein is shipped at ambient temperature. Upon arrival， Store at -20℃ Stable for Five years frozen. One month in solution at room temperature.
其他
ProSpec 是一家全球著名細胞因子蛋白生產(chǎn)和研發(fā)的公司，具有20多年的生產(chǎn)經(jīng)驗，專注于蛋白（重組及合成）生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長因子、瘦素、干細胞因子、催乳素、表皮生長因子、胰島素樣生長因子、神經(jīng)生長因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。 生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級蛋白，價格優(yōu)于同類公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標(biāo)簽蛋白?？紤]到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒有添加保護劑或鹽，這就對工藝提出了更高的要求。同時，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運輸和保存。
