產(chǎn)品新聞
背景資料
Interleukin-22 （IL-22），also known as IL-10-related T cell-derived inducible factor （IL-TIF） was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. Mouse IL-22 cDNA encodes a 179 amino acid residue protein with a putative 33 amino acids signal peptide that is cleaved to generate a 147 aa mature protein that shares approximately 79% and 22% aa sequence identity with human IL-22 and IL-10，respectively. IL-22 has been shown to activate STAT-1 and STAT-3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal mouse T cells upon Con A activation. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection，suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits，IL-22R （previously an orphan receptor named CRF2-9） and IL-10R? （previously known as CRF2-4），belonging to the class II cytokine receptor family.
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來源宿主
大腸桿菌中重組表達(dá)
溶解建議
提供的小鼠白介素-22（mIL 22）產(chǎn)品為過濾滅菌的白色凍干粉末；該凍干粉末是從含小鼠白介素-22（mIL 22）的1X PBS中凍干產(chǎn)生的.我們建議加無菌的18MΩ-cm水以配制工作儲(chǔ)存液到100ug/ml，后繼實(shí)驗(yàn)過程中可根據(jù)實(shí)驗(yàn)要求進(jìn)一步稀釋.
保存建議
小鼠白介素-22（mIL 22）在室溫可保存3周，或置于-18℃凍存用于長期保存.重新溶解后可以在4℃冷藏保存至少2-7天；如果想延長保存時(shí)間，建議分裝后置于-18℃凍存.請(qǐng)避免反復(fù)凍融.
其他
ProSpec 是一家全球著名細(xì)胞因子蛋白生產(chǎn)和研發(fā)的公司，具有20多年的生產(chǎn)經(jīng)驗(yàn)，專注于蛋白（重組及合成）生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長因子、瘦素、干細(xì)胞因子、催乳素、表皮生長因子、胰島素樣生長因子、神經(jīng)生長因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。 生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級(jí)蛋白，價(jià)格優(yōu)于同類公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標(biāo)簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒有添加保護(hù)劑或鹽，這就對(duì)工藝提出了更高的要求。同時(shí)，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運(yùn)輸和保存。
