FITC標記的磷酸化毛細血管擴張性共濟失調癥突變蛋白抗體產品介紹：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

FITC標記的磷酸化毛細血管擴張性共濟失調癥突變蛋白抗體產品信息

英文名稱	Anti-phospho-ATM (Tyr170)/FITC
中文名稱	FITC標記的磷酸化毛細血管擴張性共濟失調癥突變蛋白抗體
別名	ATM (Phospho-Tyr170); ATM (Phospho Y170); p-ATM (Tyr170); p-ATM (Y170); A-T mutated; A-T mutated homolog; AT complementation group A; AT complementation group C; AT complementation group D; AT complementation group E; AT mutated; AT protein; AT1; ATA; Ataxia angiectasia gene mutated in human beings; Ataxia angiectasia mutated; Ataxia angiectasia mutated gene; Ataxia angiectasia mutated homolog (human); Ataxia angiectasia mutated homolog; ATC; ATD; ATDC; ATE; ATM; ATM_HUMAN; DKFZp781A0353; Human phosphatidylinositol 3 kinase homolog; MGC74674; Serine protein kinase ATM; Serine-protein kinase ATM; Serine/threonine-protein kinase ATM; T cell prolymphocytic leukemia; Tefu; 1; 1, omere maintenance 1, homolog; O1; omere fusion protein; TPLL.
說明書	100ul
產品類型	磷酸化抗體
研究領域	細胞生物信號轉導細胞凋亡細胞周期蛋白激酶和磷酸酶
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, Mouse, Rat,
產品應用	ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	370kDa
性狀	Lyophilized or Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthesised phosphopeptide derived from human ATM around the phosphorylation site of Tyr170 [SV(p-Y)FR]
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
生產商	BIOSS
產品介紹	background: ATM is a 370 kDa nuclear phosphoprotein involved in the autosomal recessive disease Ataxia angiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation, apoptosis, and response to DNA damage repair (DNA damage caused by such things as ionizing irradiation activates ATM kinase). The C terminal region has extensive homology to the catalytic domains of Phosphatidylinositol 3 kinases (PI3 kinases). Function: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends.