痢疾阿米巴
痢疾阿米巴的病原體是entamebosis發(fā)生。痢疾阿米巴的營養(yǎng)階段(營養(yǎng)體)住在大腸,形成包繞的階段(囊腫)與糞便排泄。
營養(yǎng)體可以穿透腸壁,侵入肝臟及其他器官產(chǎn)生臨床amebosis形式,zui常見的腸道amebosis和肝amebosis(阿米巴肝膿腫)。
臨床癥狀可以開發(fā)zui早在感染后2 - 4周或無癥狀后幾個月,甚至幾年的時間。
以下腸道形式出現(xiàn):
- 入侵腸道形態(tài)結果腸壁的病原體的入侵和反映了大腸疾病。急性疾病通常開始于腹部不適,發(fā)作的腹瀉持續(xù)時間不同,起初糊狀的增加黏液狀的,包括一旦凳子。自然可以緩解癥狀,但經(jīng)常再犯慢性結腸炎的發(fā)展,可以持續(xù)幾個月,甚至幾年。
- 在大多數(shù)情況下,無癥狀的腸道形成運行無癥狀。隨便感染診斷出患有凳子上測試(營養(yǎng)體??更頻繁的囊腫在凳子上)。
- Extraintestinal形式出現(xiàn)在ca。30%的感染。zui常見的形式是所謂的?肝膿腫嗎?,在肝阿米巴原蟲的傳播。肝膿腫引起弛張熱(有時高),上腹痛、肝腫大、高程的隔膜、全身無力等癥狀。大不及時治療肝膿腫通常是致命的。
痢疾阿米巴感染發(fā)生在世界范圍內,普遍在溫暖的國家。在流行地區(qū),在非洲、亞洲和南美洲70 - 90%的人口可以痢疾阿米巴的載體。感染是由囊腫從一個人傳播到另一個由于傳播成熟的囊腫和受污染的食品(果蔬),飲用水或糞便污染的手。蒼蠅和蟑螂可以從糞便作為中介,囊腫excretor的食物。每年新發(fā)病例的數(shù)量估計在4800萬年,約有70 000致命的結果(,1998)。
物種 | 感染的機制 | 癥狀 | 并發(fā)癥 | 診斷 |
痢疾阿米巴 | 口周圍的攝入、飲用水、食物 | 沒有超過90%(無癥狀,腸道形式)出現(xiàn)大便,腹瀉、敗血癥 | 腹部出血、結腸炎、肝膿腫、腹膜炎 | 顯微鏡臨床血清學方法(超音波,電腦斷層掃描等) |
感染的診斷則需要通過:
- 顯微鏡:確定寄生蟲在凳子上
- 血清學:特定抗體基于ELISA-technique的決心
NovaLisa嗎?痢疾阿米巴免疫球蛋白ELISA:
NovaLisa嗎?痢疾阿米巴免疫球蛋白ELISA用于定性測定IgG-class抗體痢疾阿米巴在人類血清或血漿(檸檬酸)。
抗原:
純化痢疾阿米巴Trophozoit抗原
具體的性能特征:
| Intraassay | Interassay | 靈敏度 | 特異性 | ||||
| n | 的意思是 | CV % | n | 目的 | CV % |
|
|
免疫球蛋白 | 7 | 0.609 | 2.1 | 6 | 0.604 | 3.9 | > 95% | > 95% |
訂單信息:
ELISA | 的數(shù)量決定 | 產(chǎn)品編號 |
痢疾免疫球蛋白 | 96年 | ENTG0140 |
Entamoeba histolytica
Entamoeba histolytica is the causative agent of the worldwide occurring entamebosis. The vegetative stages (trophozoites) of Entamoeba histolytica live in the large intestine and form encysted stages (cysts) that are excreted with feces.
The trophozoites can penetrate into the intestinal wall and invade the liver and other organs to produce clinical forms of amebosis, most frequently intestinal amebosis and hepatic amebosis (amoebic liver abscess).
Clinical symptoms can develop as early as 2-4 weeks after infection or after asymptomatic periods of months or even years.
The following intestinal forms occur:
- The invasive intestinal form results from the invasion of the intestinal wall by the pathogen and reflects large intestine disease. The acute disease usually begins with abdominal discomfort and episodes of diarrhea of varying duration, at first mushy the increasing mucoid, including blood-tinged stool. The symptoms may abate spontaneously, but fairly often a recidivating chronic colitis develops that can last for months or even years.
- In most cases the asymptomatic intestinal form runs asymptomatic. The infection is casually diagnosed with a stool test (Trophozoites and more frequent cysts in stool).
- Extraintestinal forms appear in ca. 30 % of all infections. The most frequent form is the so called ?liver abscess?, the spread of amoebas in liver. The liver abscess causes remittent fever (sometimes high), upper abdominal pain, liver enlargement, elevation of the diaphragm, general weakness and other symptoms. Large liver abscesses that are not treated in time are often lethal.
Infections of Entamoeba histolytica occur worldwide, prevalent in warmer countries. In endemic areas in Africa, Asia and Central and South America up to 70-90% of the population can be carriers of Entamoeba histolytica. The infection is transmitted by cysts from one human to another due to transmission of mature cysts with contaminated foods (fruit vegetables), drinking water or fecally contaminated hands. Flies and cockroaches can function as intermediaries by carrying cysts from the feces of an excretor to foods. Worldwide the annual number of new cases is estimated at 48 million, with about 70 000 lethal outcomes (WHO, 1998).
Species | Mechanism of Infection | Symptoms | Complications | Diagnostic |
Entamoeba histolytica | Peroral ingestion,drinking water, foods | With more than 90% no (asymptomatic, intestinal form)blood-tinged stools, diarrhea, sepsis | Abdominal bleeding, colitis,liver abscess, peritonitis | Microscopy Serology Clinical methods(Ultrasound, computer tomography, etc.) |
Infections may be diagnosed by:
- Microscopy: Determination of parasites in stool
- Serology: Determination of specific antibodies based on the ELISA-technique
NovaLisa? Entamoeba histolytica IgG ELISA:
The NovaLisa? Entamoeba histolytica IgG ELISA is intended for the qualitative determination of IgG-class antibodies against Entamoeba histolytica in human serum or plasma (citrate).
Antigens:
Purified Entamoeba histolytica Trophozoit antigens
Specific performance characteristics:
| Intraassay | Interassay | Sensitivity | Specificity | ||||
| n | Mean | CV% | n | Meam | CV% |
|
|
IgG | 7 | 0.609 | 2.1 | 6 | 0.604 | 3.9 | >95% | >95% |
Order information:
ELISA | Number of Determinations | Product Number |
Entamoeba IgG | 96 | ENTG0140 |
