Anti-ATF3
Catalog Number : Rs-0519R
Quantity size : 0.1ml (dilute with pH 7.4 0.01 M PBS or antibody diluent )
Background:
Theactivating transcription factor 3 belong to contain the turn of sour zipperstructure of bright ammonia to record the factor ATF/ CREB household member,present the low density Stable appearance expression in big and part of normalcell.The ATF3 not only in should arouse respond is adjusts to control thefactor decisively, but also participated the machine body Stable appearancemaintenance, wound extensively to match more, the cell sticks to attach,physiologies such as the tumor formation, Apoptosis and the signal conductionetc. and pathologic process.The ATF3 and the cell existences have relation withApoptosis.
Function: This protein binds the cAMP response element (CRE) (consensus:5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellularpromoters. Represses transcription from promoters with ATF sites. It mayrepress transcription by stabilizing the binding of inhibitory cofactors at thepromoter. Isoform 2 activates transcription presumably by sequesteringinhibitory cofactors away from the promoters.
Similarity: Belongs to the bZIP family. ATF subfamily.
Contains1 bZIP domain
.pecificity:
- Anti-ATF3 is a Rabbit polyclonal antibody unconjugated
specific for ATF3 of Human, Mouse, Rat, Chicken, Dog, Cow,
use for western blotting,elisa,immunoprecipitation andimmunohistochemistry
– Protein G affinity chromatography purification,purity :>95%
– Isotype: IgG
Application :
– WB=1:100-500 ELISA=1:500-1000 IP=1:20-100IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user..
Storage: Store at-20℃ for one year.Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least onemonth and for greater than a year whenkept at -20℃. Whenreconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody, the antibody is stable for atleast six weeks at 2-4 ℃
Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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