Anti-CDKN2A/p14ARF抗體,抑癌基因p14抗體科研產品介紹：
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. CDKN2A.
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產品詳情：
產品編號：HRK-1174R
產品規格: 0.1ml/0.2ml
產品別名：CD2A2_HUMAN; p14 ARF; TP16; p16; CDKN2; MTS1; INK4a; CMM2; MLM; ARF; p16INK4a; INK4; p16-INK4a; p14; p16-INK4; p16INK4A; p16INK4; p19; p19ARF; CDK4I; MTS-1
產品價格：詢價(電詢或客服)
產品用途：科研實驗
貯 存： 貯存于-20℃.
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