Panbio登革熱IgG/IgM抗體檢測試劑（膠體金法）

廣州健侖生物科技有限公司

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Panbio登革熱IgG/IgM抗體檢測試劑（膠體金法）

非洲工作用登革熱試紙

熱帶國家旅游用登革熱檢測試紙

登革熱IgM抗體、登革熱IgG抗體、登革熱NS1抗原、登革熱早期檢測試劑盒

登革熱核酸檢測試劑盒

Panbio公司簡介:
1、1988年成立，2001年在澳大利亞證券交易所上市。
2、Panbio系關于蟲媒感染性疾病及熱帶感染性疾病的專業供貨商。
3、產品面向蟲媒感染性疾病的檢測，在國內疾控系統具有*的認知和認可度。
4、2010年銷售800萬檢測試劑，為30多種疾病提供診斷。

Panbio登革熱介紹：

1、登革熱快速檢測試劑(Dengue Duo Cassette R-DEN03D)
用于定性的快速檢測人群血清、血漿或全血中登革病毒的IgM及IgG抗體?？稍?5分鐘內檢測結果。

2、登革IgM捕捉ELISA(Dengue IgM Capture ELISA E-DEN01M)
用于定性的檢測人群血清中登革病毒的IgM抗體，用于臨床實驗室對具有持續發燒的登革熱癥狀的病人的輔助診斷。

3、登革IgG捕捉ELISA(Dengo IgG Capture ELISA E-DEN02G)
用于定性檢測血清中登革病毒(血清型1、2、3及4型)的IgG抗體。用于臨床實驗室對繼發登革熱感染的輔助診斷。

4、登革早期ELISA(Dengue Early ELISA E-DEN01P)
用于定性檢測血清中登革病毒的NS1抗原(血清型1、2、3及4型)。用于臨床實驗室對有持續發燒的登革熱癥狀病人的輔助性診斷。

5、登革IgG間接ELISA(Dengue IgG Indirect ELISA E-DEN01G)
用于定性檢測血清中登革病毒(血清型1、2、3及4型)的IgG抗體，用于臨床實驗室對具有持續發燒的登革感染癥狀或接觸史的患者的輔助性診斷。

6、登革IgM & IgG聯檢ELISA(Dengue Duo IgM & IgG Capture ELISA E-DEN01D)
用于定性檢測血清中登革病毒的IgM和IgG抗體。可以區分原發感染與繼發感染。

Dengue產品介紹

Panbio

流行情況/登革熱病 panbio登革熱
人類記載的*次登革熱病流行發生在1648年的墨西哥的尤卡坦半島。此前在加勒比海地區已有該病存在。
17至19世紀，該病通過交通運輸、人員流動傳人北美和歐洲后，成為美洲、非洲及歐洲部分地區zui嚴重的傳染病之一，曾造成人群大量死亡及部分社會活動癱瘓。
1741年，英國27000名士兵攻打哥倫比亞，因20000人感染登革熱病而潰不成軍；1762年英國殖民軍侵略古巴，15000名士兵中8000人死于登革熱病；
1793年，美國費城登革熱病大流行，全市1/5人口死于登革熱病，導致社會*解體。其后疫情沿密西西比河深人到北美中心地帶，美國至少有50萬人罹患此?。?br />1800年，西班牙發生登革熱病，死亡至少6萬人；
1851年，巴西首都里約熱內盧因登革熱病至少死亡23000人；
巴拿馬運河開鑿*期工程中曾因本病嚴重流行而迫使工程停頓；
1826年英國殖民者人侵非洲時發生本病，535名殖民軍在兩個月中死亡115人；
1940年以前，登革熱病在非洲同樣是大小流行不斷造成人員大量死亡。
1959年，扎尹爾和蘇丹相繼出現暴發流行。1960～1962年埃塞俄比亞發生嚴重大流行，100萬人口中約10%感染本病，其中死亡3萬人。
20世紀60年代以來，非洲和南美洲的登革熱病暴發一直未曾中斷。每年向世界衛生組織報告的病例數波動在近百例至數千例不等。
1987～1991年間，登革熱病在尼日利亞流行，幾十萬人受到感染。
2012年11月1日，位于蘇丹西部的中達爾富爾州和南達爾富爾州有47名公民感染登革熱病死亡，蘇丹登革熱病患者已超過92例。登革熱 至2012年11月5日，蘇丹達爾富爾地區登革熱病疫情，疑似病例達到194例，其中包括67例死亡病例，死亡率為34.5%。登革熱
病Panbio登革熱理/登革熱病 panbio登革熱
病原學
病原為登革熱病病毒（yellow fever virus），屬黃病毒科（family Flaviviridae）的黃病毒屬（genus Flavivirus）（過去的蟲媒病毒B組）與同屬的登革熱病毒等有交叉免疫反應。病毒顆粒呈球形，直徑37～50nm，外有脂蛋白包膜，包膜表面有刺突。病毒基因組為單股正鏈RNA，分子量約為3.8×106 ，長約11kb，只含有一個長的開放讀碼框架，約96%的核苷酸在此框架內。黃病毒基因組分為二個區段：5'端1/4編碼該病毒3個結構蛋白，即C蛋白（衣殼蛋白）、M蛋白（膜蛋白）和E蛋白（包膜蛋白）；3'端3/4編碼7個非結構蛋白?；蚪M的5'端和3'端均有一段非編碼區。
E蛋白是主要的包膜糖蛋白，含Panbio登革熱毒血凝素和中和抗原決定簇，可能是某些宿主細胞表面受體的配體，當它與受體結合，可對細胞產生感染。E蛋白可能是一種膜融合蛋白，可誘導病毒顆粒的包膜與細胞膜融合，促使病毒顆粒進入細胞而引起感染。M蛋白能導致病毒的感染性增加，并形成病毒顆粒的表面結構。非結構蛋白的作用尚不十分清楚，在病毒免疫反應中可能起重要作用。
登革熱病病毒有嗜內臟如肝、腎、心等（人和靈長類）和嗜神經（小鼠）的特性。經雞胚多次傳代后可獲得作為疫苗的毒力減弱株。易被熱、常用消毒劑、Panbio登革熱、去氧膽酸鈉等迅速滅活，在50%甘油溶液中可存活數月，在凍干情況下可保持活力多年。小鼠和恒河猴是常用的易感實驗動物。
發病機理
病毒侵入人體后擴散到局部淋巴結，并在其中復制繁殖，數日后進入血循環形成病毒血癥，主要累及肝、脾、腎、淋巴結、骨髓、橫紋肌等。以后病毒從血中消失，而在脾、骨髓、淋巴結等處仍可檢出。病毒的強毒株常主要侵犯肝臟，并引起嚴重病變。
病理改變
登革熱病的病理變化乃病毒聚集于各器官組織，并在其中復制增殖所引起。肝病變主要見于小葉中間帶，肝細胞呈濁腫、點狀凝固性壞死及嗜酸性透明變性，形成具相當特征性的康氏小體（Councilman bodies）；嚴重肝病變可導致深度黃疸、各處出血、低血糖等。Panbio登革熱變輕重不一；見于近曲小管，小管上皮濁腫、脫落或壞死，管腔充塞顆粒樣碎屑；腎功能減退和尿毒癥乃血容量減少、腎小管壞死等所引起。心肌有廣泛退行性變和脂肪浸潤，偶有灶性出血，病變常累及竇房結和希氏束；臨床上可出現心率減慢、心律失常、低血壓、心力衰竭等。腦部偶見水腫及灶性出血，系繼發于腦組織缺氧和乳酸血癥等代謝改變，而非病毒直接侵犯所致。各臟器組織元炎癥細胞浸潤，此乃本病的特征之一。出血傾向與血小板減少、血小板功能異常和凝血因子減少有關。

Panbio

我司還提供其它進口或國產試劑盒：登革熱、瘧疾、乙腦、寨卡、黃熱病、基孔肯雅熱、克錐蟲病、違禁品濫用、肺炎球菌、軍團菌等試劑盒以及日本生研細菌分型診斷血清、德國SiFin診斷血清、丹麥SSI診斷血清等產品。

想了解更多的Panbio產品及服務請掃描下方二維碼：

【公司名稱】 廣州健侖生物科技有限公司
【市場部】    楊永漢

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【騰訊  】 2042552662
【公司地址】 廣州清華科技園創新基地番禺石樓鎮創啟路63號二期2幢101-103室

references：

Epidemic situation / dengue fever panbio dengue fever
The first recorded dengue fever epidemic in humans occurred in the 1648 Mexican Yucatan Peninsula. The disease had previously existed in the Caribbean.
From the 17th to the 19th century, the disease became one of the most serious infectious diseases in the Americas, Africa and parts of Europe through transportation and personnel transmission to North America and Europe, which caused a large number of deaths and paralysis of some social activities.
In 1741, the United Kingdom 27,000 soldiers attacked Colombia, due to 20,000 people infected with dengue fever and failed; 1762 British colonial army invaded Cuba, 15,000 soldiers in 8000 people died of dengue fever;
In 1793, the United States Philadelphia dengue fever pandemic, the city's 1/5 population died of dengue fever, leading to the community compley disintegrated. Followed by the epidemic along the Mississippi River deep to the North American center, the United States at least 50 million people suffering from the disease;
In 1800, dengue fever occurred in Spain, killing at least 60,000 people;
In 1851, the Brazilian capital Rio de Janeiro died of dengue fever at least 23,000 people;
Panama Canal digging the first phase of the project because of the serious epidemic and forced the project to stop;
1826 British colonial invasion of Africa when the disease, 535 colonial troops died in two months 115;
1940 years ago, dengue fever in Africa is also the size of the popular continue to cause a large number of deaths.
In 1959, Zaire and Sudan have been outbreaks. 1960 ~ 1962 Ethiopia serious pandemic, 1 million people about 10% of the population infected with the disease, of which 30,000 people died.
Since the 1960s, dengue fever outbreaks in Africa and South America have not been interrupted. The number of cases reported annually to the World Health Organization varies from nearly one hundred to several thousand cases.
Between 1987 and 1991, dengue fever was prevalent in Nigeria and hundreds of thousands of people were infected.
On November 1, 2012, 47 people in Darfur and Southern Darfur in western Sudan were infected with dengue fever and more than 92 cases of dengue fever in Sudan. Dengue fever to November 5, 2012, Sudan, Darfur region dengue fever epidemic, suspected cases reached 194 cases, including 67 cases of death, the mortality rate was 34.5%. dengue
Sick Panbio dengue fever / dengue fever panbio dengue fever
Etiology
The genotype Flavivididae (genus Flavivirus), a genus Flaviviridae, has a cross-immune response with the same genus dengue virus. Virus particles were spherical, diameter 37 ~ 50nm, outside the lipoprotein capsule, capsule surface spikes. The viral genome is a single stranded stranded RNA with a molecular weight of about 3.8 x 106 and a length of about 11 kb, containing only a long open reading frame, about 96% of the nucleotides within this framework. The flavivirus genome is divided into two sections: the 5 'end 1/4 encodes the three structural proteins of the virus, namely protein C (capsid protein), M protein (membrane protein) and E protein (envelope protein) Terminal 3/4 encodes 7 nonstructural proteins. The 5 'and 3' ends of the genome have a noncoding region.
E protein is the main envelope glycoprotein, containing Panbio dengue fever hemagglutinin and neutralizing antigenic determinants, which may be ligands of certain host cell surface receptors, when it binds to receptors and can infect cells. E protein may be a membrane fusion protein that can induce the envelope of the viral particles to fuse with the cell membrane, causing the virus particles to enter the cell and cause infection. M protein can cause increased infectivity of the virus and form the surface structure of the virus particles. The role of nonstructural proteins is not yet clear and may play an important role in the viral immune response.
Dengue fever virus has the characteristics of nausea such as liver, kidney, heart (human and primate) and neurotropic (mouse). After repeated passage of chicken embryos can be obtained as a virulence of the vaccine attenuated strain. Easy to be hot, commonly used disinfectants, Panbio dengue fever, sodium deoxycholate and other rapid inactivation, in 50% glycerol solution can survive for several months, in the case of freeze can remain viable for many years. Mice and rhesus are commonly used susceptible experimental animals.
Pathogenesis
After the virus invades the human body after the spread to the local lymph nodes, and in which reproduction and reproduction, a few days later into the blood circulation to form viremia, mainly involving the liver, spleen, kidney, lymph nodes, bone marrow, striated muscle and so on. After the virus disappeared from the blood, and in the spleen, bone marrow, lymph nodes, etc. can still be detected. Virus virulent strains often violate the liver and cause serious lesions.
Pathological changes
The pathological changes of dengue fever are caused by the accumulation of viruses in various organs and tissues. Liver lesions are mainly seen in the middle lobes, the liver cells are turbid, dot-like coagulation necrosis and eosinophilic transparent degeneration, the formation of a very characteristic of the body of the body (Councilman bodies); severe liver disease can lead to deep jaundice, everywhere Bleeding, hypoglycemia and so on. Panbio dengue fever varies severity; seen in the proximal tubule, tubule epithelium swelling, shedding or necrosis, luminal filling of granular debris; renal dysfunction and uremia is caused by reduced blood volume, renal tubular necrosis and so on. Myocardium has a wide range of degenerative changes and fat infiltration, occasional focal bleeding, lesions often involving sinus node and Xi bundle; clinical can be heart rate, arrhythmia, hypotension, heart failure and so on. Brain edema and focal bleeding, the Department of secondary to brain tissue hypoxia and lactic acid and other metabolic changes, rather than a direct violation of the virus. Each organ tissue element inflammatory cell infiltration, which is one of the characteristics of the disease. Hemorrhagic tendency is associated with thrombocytopenia, abnormal plaet function, and reduced coagulation factors.