西班牙Certest呼吸道合胞病毒單抗（克隆RV3）

廣州健侖生物科技有限公司

廣州健侖長期供應各種生物原料，主要代理品牌：西班牙Certest。

主要產品包括各種生物單克隆抗原抗體、重組蛋白。

西班牙Certest呼吸道合胞病毒單抗（克隆RV3）

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這項研究意味著人們可以開發出精確的基因療法來預防和治療疾病，是高度個性化醫療的曙光。個性化醫療是非常重要的，因為人的個體差異對疾病發展影響很大。
CRISPR/Cas9是時下zui熱門的基因編輯系統，Cas9蛋白可以說是基因工程的瑞士抗原抗體，可以結合并切割任意DNA。Church等人以一種新方式使用Cas9，讓它激活特定基因的轉錄，從而表達或抑制特定的遺傳學性狀。他們把Cas9與延長了三倍的轉錄因子融合起來，使其能夠強力控制單個或多個基因的表達。
“在基因工程領域，能控制遺傳學性狀的旋鈕越多越好，”Church說。“我們展示了一類全新的旋鈕，它們可以控制多個基因，決定特定遺傳學性狀的表達或表達程度。現在我們可以極為精確的上調或下調基因表達。”研究人員在體外培養的酵母、果蠅、小鼠和人類細胞中證實了這一技術操縱基因表達的能力。
人類基因組90%的區域并不翻譯成蛋白質，曾經被認為是無用的垃圾。后來人們發現，這一區域的基因以一種神秘的方式起作用，而且這些基因往往串聯起來發揮作用。Church等人開發的新方法，可以靶標和激活這些人們知之甚少的DNA暗物質。
除了揭開DNA暗物質的秘密，Cas9還能將合成的基因環引入基因組，觸發全新的基因表達或者改變基因表達。用 Cas9精確操縱一連串基因，對干細胞工程也有很大的幫助，有助于開發移植用的器官和再生療法。
“要從干細胞抗原抗體官，我們必須加快對發育生物學的理解，”Church說。“我們的方法可以快速干擾和分析大量基因組合，大大提升鑒定發育通路的速度。”
研究人員用自己開發的技術誘導干細胞分化成大腦神經元。他們發現，Cas9在編程神經元發育時比傳統方法好40倍。
“這項研究為人們提供了控制細胞和組織功能的有力途徑，會給所有科研和醫療領域帶來一場革命，比如基因治療、再生醫學、抗衰老等等，”Wyss研究所的Donald Ingber教授說。
揮之不去的霧霾對公眾健康產生的影響給社會帶來強烈擔憂，其對整個社會的正常生產、生活造成了巨大影響。霧霾是漂浮大氣中的PM2.5等尺寸微粒、粉塵、氣溶膠等粒子，其中PM2.5顆粒對人類危害zui大，有研究表明，PM2.5顆粒可對呼吸系統和心血管系統造成傷害，導致人類平均壽命減少8.6個月。面對如此嚴重的問題，如何治理大氣污染，治理霧霾，還人類一個沒有污染的藍天已迫在眉睫。

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【公司名稱】 廣州健侖生物科技有限公司
【市場部】    楊永漢

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【公司地址】 廣州清華科技園創新基地番禺石樓鎮創啟路63號二期2幢101-103室

This research means that people can develop precise gene therapy to prevent and cure diseases, which is the dawn of highly personalized medicine. Personalized medical care is very important, because individual differences in human beings have a great impact on disease development.
CRISPR / Cas9 is the hottest gene editing system of the moment. Cas9 protein is a genetically engineered Swiss antigen antibody that binds and cleaves any DNA. Church et al. Use Cas9 in a new way to activate the transcription of specific genes to express or suppress specific genetic traits. They fused Cas9 with a threefold-longer transcription factor, enabling them to aggressively control the expression of single or multiple genes.
"In genetic engineering, the more knobs that control genetic traits, the better," Church said. "We showed a new class of knobs that control multiple genes and determine the level of expression or expression of specific genetic traits, and we can now very accuray up-regulate or down-regulate the gene." The researchers studied in vitro yeast The ability of the technique to manipulate gene expression is confirmed in flies, mice and human cells.
Ninety percent of the human genome is not translated into protein and was once considered useless rubbish. It was later discovered that the genes in this area functioned in a mystical way, and these genes tended to work in tandem. The new method developed by Church et al. Targets and activates these poorly understood DNA dark substances.
In addition to revealing the secrets of DNA dark matter, Cas9 can also introduce synthetic gene loops into the genome, triggering entirely new gene expression or altering gene expression. The precise manipulation of a series of genes with Cas9 is also a great help to stem cell engineering and helps to develop organs for transplantation and regenerative therapies.
"From stem cell antigen antibodies, we have to speed up the understanding of developmental biology," Church said. "Our approach quickly interferes with and analyzes a large number of combinations of genes and greatly increases the speed of identifying developmental pathways."
Researchers use their own technology to induce stem cells to differentiate into neurons in the brain. They found that Cas9 is 40x better at developing programmed neurons than the traditional method.
"This research provides a powerful way for people to control the function of cells and tissues and brings about a revolution in all scientific research and medical fields such as gene therapy, regenerative medicine, anti-aging and so on," said Professor Donald Ingber of the Wyss Institute Say.
The impact of the lingering smog on public health has brought strong concerns to the community and has had a huge impact on the normal production and life of the entire society. Haze is floating in the atmosphere such as PM2.5 size particles, dust, aerosols and other particles, of which PM2.5 particles most harmful to humans, studies have shown that PM2.5 particles can cause respiratory and cardiovascular system damage, Resulting in a decrease of 8.6 months in average human life expectancy. In the face of such a serious problem, it is imminent to deal with air pollution and to control smog and haze, as well as a blue sky without pollution.