西班牙Certest滅活的大腸桿菌抗原（天然提取物）

廣州健侖生物科技有限公司

廣州健侖長期供應各種生物原料，主要代理品牌：西班牙Certest。

主要產品包括各種生物單克隆抗原抗體、重組蛋白。

西班牙Certest滅活的大腸桿菌抗原（天然提取物）

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ohn Cooke教授表示，據我們所知，本文研究是*利用小分子和蛋白來完成治療細胞類型的分化轉移，在特殊情況下我們就可以將成纖維細胞轉化成為所需的細胞類型。文章中研究者首先將成纖維細胞暴露于多聚胞苷酸(polyinosinic-polycytidylic acid，poly I：C)中，雙鏈RNA分子的一小部分會結合宿主細胞的TLR3(toll樣受體3)來“哄騙”細胞好像針對病毒攻擊那樣產生反應;在2012年發表在Cell上的一篇研究文章中，Cooke教授就揭示了成纖維細胞對病毒攻擊的反應，在利用poly I：C處理成纖維細胞后，研究者觀察到了細胞核染色質的重新組裝，這種組裝可以使得之前關閉的基因重新表達，隨后利用諸如VEGF等因子對成纖維細胞進行處理，就可以將少量分化的細胞轉化成為內皮細胞。
在這項研究中，研究者報道可以將2%的成纖維細胞轉化成為內皮細胞，這種比例可以和其它利用病毒及基因療法得到的轉化率等同，但Cooke補充道，目前我們可以使得轉化率高達15%;我們并不想讓所有的成纖維細胞都發生轉化，因為成纖維細胞還發揮著非常重要的作用，文章中我們只是促進部分的抗原抗體細胞轉化成為血管細胞，從而為損傷組織提供血液供給。
隨著研究的深入，研究者將已經轉化的人類細胞(血管細胞)引入到免疫缺陷的小鼠機體中，這些小鼠下肢的血液流動較差，研究者發現人類的血管細胞可以增加小鼠下肢的血管數量，有效改善其血液循環。這些血管細胞可以自發形成血管組織;下一步研究人員想去研究是否其可以拯救受傷的動物，如果該療法可以通過增加受損組織的血液流動從而達到治愈的目的，那么其或許就為開發治療局部缺血等一系列疾病的新型療法提供希望。
食道癌是癌癥死亡的第六大原因，是存活zui少的癌癥之一，食道癌在不同人口中的發病率顯示出巨大的差異，這就表明環境或生活方式是可以控制減少這些疾病風險的因素。
食道上皮惡性腫瘤有兩個主要的病理類型，即鱗狀細胞癌和腺癌。zui近，在發達國家腺癌發病率正在增加，在美國50%以上是腺癌，尤其是在白人男性，約為70%是腺癌。食管腺癌發生在食管的下部。與此形成鮮明對比的是，在日本，腺癌的增加并不清楚，大多數(90%)的食管癌都是鱗狀細胞癌，這樣的鱗狀細胞癌大多發生在食管中段，60%或更多的食道癌也發生在中部和上部。這些差異都會影響治療的結果。
日本岐阜市醫院診斷病理學Naoki Watanabe通過對食道癌組織病理學特點及分子機制的概述，討論了食道的致癌作用，文章發表在科研出版社英文期刊《Open Journal of Pathology》(病理學期刊)2014年10月刊上。

西班牙Certest滅活的大腸桿菌O157抗原（天然提取物）

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【公司名稱】 廣州健侖生物科技有限公司
【市場部】    楊永漢

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Professor Ohn Cooke said that, to our knowledge, this study is the first to utilize small molecules and proteins to complete the differentiation and metastasis of treated cell types. Under special circumstances, we can transform fibroblasts into desired cell types. In the article, researchers first exposed fibroblasts to polyinosinic-polycytidylic acid (poly I: C), and a small portion of the double-stranded RNA molecule binds to the host cell's TLR3 (toll-like receptor 3) "Kidding" cells seem to react as they did to virus attacks; in a research article published in the Cell in 2012, Professor Cooke revealed the fibroblast response to viral challenge by treating fibroblasts with poly I: C After the researchers observed a reassembly of the chromatin in the nucleus, this assembly allows the previously closed gene to be re-expressed, followed by treatment of fibroblasts with factors such as VEGF, which can transform small numbers of differentiated cells into endothelial cells.
In this study, researchers report that 2% of fibroblasts can be transformed into endothelial cells, which is equivalent to other rates of virus and gene therapy conversion, but Cooke added that we can now convert Up to 15%. We do not want to transform all the fibroblasts because fibroblasts play a very important role. In this article, we only promote part of the antigen-antibody cells into blood vessels to provide blood to damaged tissues supply.
With further research, researchers introduced already transformed human cells (vascular cells) into immunocompromised mice. The blood flow in the lower extremities of these mice was poor. The researchers found that human vascular cells can increase the number of lower extremities The number of blood vessels, effectively improve their blood circulation. These vascular cells spontaneously develop into vascular tissue; the next step researchers want to investigate is whether it can save an injured animal, and if the therapy can be cured by increasing the blood flow in the damaged tissue for the purpose of healing Ischemia and a series of new diseases such as therapies provide hope.
Esophageal cancer is the sixth leading cause of cancer deaths and one of the least survivors of cancer. The incidence of esophageal cancer in different populations shows a huge difference, indicating that the environment or lifestyle is the factor that can control the risk of reducing these diseases .
Esophageal malignancies have two major pathological types, squamous cell carcinoma and adenocarcinoma. Recently, the incidence of adenocarcinoma is increasing in developed countries, with more than 50% of adenocarcinomas in the United States, especially in white men, and about 70% are adenocarcinomas. Esophageal adenocarcinoma occurs in the lower part of the esophagus. In sharp contrast, in Japan, the increase in adenocarcinoma is not clear, and most (90%) of esophageal cancers are squamous cell carcinomas. Most of these squamous cell carcinomas occur in the middle of the esophagus, and 60% or More esophageal cancer also occurs in the middle and upper part. These differences will affect the outcome of treatment.
Diagnostic Pathology in Gifu City, Japan Naoki Watanabe discusses the carcinogenicity of the esophagus through an overview of the histopathological features and molecular mechanisms of esophageal cancer. The article was published in the journal Open Journal of Pathology 2014 In October issue.