西班牙Certest滅活的肺炎鏈球菌抗原（天然提取物）

廣州健侖生物科技有限公司

廣州健侖長期供應各種生物原料，主要代理品牌：西班牙Certest。

主要產品包括各種生物單克隆抗原抗體、重組蛋白。

西班牙Certest滅活的肺炎鏈球菌抗原（天然提取物）

我司還提供其它進口或國產試劑盒：登革熱、瘧疾、流感、A鏈球菌、合胞病毒、腮病毒、乙腦、寨卡、黃熱病、基孔肯雅熱、克錐蟲病、違禁品濫用、肺炎球菌、軍團菌、化妝品檢測、食品安全檢測等試劑盒以及日本生研細菌分型診斷血清、德國SiFin診斷血清、丹麥SSI診斷血清等產品。

歡迎咨詢

歡迎咨詢2042552662

【產品介紹】

西班牙

科學家們指出，在健康的年輕小鼠中，GD3非常充足，但是它似乎隨著年齡增長而自然地減少。
2013年，于教授和Wang在《PNAS》發表的一項研究表明，GD3是小鼠神經干細胞中的主要神經節苷脂，在那里它與表皮生長因子受體相互作用，也被發現存在于細胞表面。GD3在生長因子信號中發揮重要的作用，反過來，又告訴神經干細胞增殖或死亡。
Wang說：“在正常情況下，生長因子可以使神經干細胞能夠產生更多的干細胞。這使我們更好地了解，在我們一生中，我們的神經干細胞群是如何被維持的。我們的長期目標是，利用內源性神經干細胞，修復大腦或脊髓損傷，所以我們需要學習它們是如何增殖的，如何讓它們保留在大腦里。”
這兩種想法都是樂觀的，有一天，操縱生長因子和含糖脂肪的水平，將使我們一生中具有更堅定的神經干細胞供應，雖然使這些物質進入大腦是一種挑戰。我們已經知道，至少在大鼠當中，鍛煉也可以有所幫助。
于教授說，神經干細胞能夠不斷地自我更新，至少在理論上是這樣。它們能夠維持自我的一個穩定供應，以分化為不同類型的腦細胞，這是它們zui重要的性能。
近日，來自牛津大學的科學家通過研究，揭示了控制機體上皮細胞形狀和運動狀態發生轉變的關鍵機制，相關研究刊登于雜志Nature Cell biology上;文章中研究者表示，名為ASPP2的腫瘤抑制蛋白的功能就好比是一種分子開關，其可以控制并且逆轉機體上皮細胞的形狀及運動狀態的改變，這對于解釋一系列生化現象，比如傷口愈合、胚胎發育及癌癥轉移都非常關鍵。
研究者Xin Lu表示，目前我們盡力去鑒別出控制控制上皮細胞可塑性的分子開關，這樣的可塑性是癌癥的標志，為了發生轉移，癌細胞會疏松自身的結構，不斷擺動脫離母體腫瘤組織，進而在機體其它組織器官部位“安家”，上述的過程就稱為上皮細胞向間充質細胞的轉分化過程及間質細胞向上皮細胞的轉化過程(EMT及MET)。
研究者發現，在腎小管的發育過程中ASPP2蛋白會促使MET過程的發生，從而過濾掉機體血液中的廢棄物，而當ASPP2蛋白缺失時會促進EMT過程的發生，尤其是在表達常見癌癥基因RAS細胞中，EMT過程尤為明顯，從而就會引發癌癥發生轉移。隨后研究人員對小鼠模型進行試驗發現，當小鼠機體中抗原抗體癌細胞表達較低水平的ASPP2時，其就會大量轉移至大腦細胞中，如果這些抗原抗體癌細胞表達較足量的ASPP2，其轉移的能力就會明顯下降。

西班牙

想了解更多的產品及服務請掃描下方二維碼：

【公司名稱】 廣州健侖生物科技有限公司
【市場部】    楊永漢

【】 
【騰訊  】 2042552662
【公司地址】 廣州清華科技園創新基地番禺石樓鎮創啟路63號二期2幢101-103室

Scientists point out that GD3 is abundant in healthy young mice, but it appears to naturally decrease with age.
In 2013, professors and Wang published a study in "PNAS" that GD3 is the dominant ganglioside in mouse neural stem cells, where it interacts with the epidermal growth factor receptor and is also found in cells surface. GD3 plays an important role in growth factor signaling, in turn, ling neural stem cell proliferation or death.
"Under normal circumstances, growth factors can make neural stem cells produce more stem cells, which allows us to better understand how our neural stem cell population is maintained throughout our life." Our long-term goal Yes, using endogenous neural stem cells to repair brain or spinal cord injury, so we need to learn how they proliferate and how to keep them in the brain. "
Both of these ideas are optimistic. One day, manipulating the levels of growth factors and sugary fats will give us a firmer supply of neural stem cells throughout our lives, although getting them into the brain is a challenge. We already know that exercise can be helpful, at least in rats.
Professor Yu said that neural stem cells are constantly self-renewing, at least in theory. They are able to maintain a stable supply of self to differentiate into different types of brain cells, which is their most important performance.
Recently, scientists from Oxford University revealed the key mechanisms that control the change of the epithelial cell shape and movement in the body. Relevant research is published in the journal Nature Cell Biology. In the article, researchers said that the tumor suppressor protein called ASPP2 Is like a molecular switch that controls and reverses changes in the shape and motility of the body's epithelium, which is crucial for interpreting a range of biochemical phenomena such as wound healing, embryonic development, and cancer metastasis.
Xin Lu, a researcher, said that at present we try our best to identify molecular switches that control the plasticity of epithelial cells. Such plasticity is a hallmark of cancer. In order to metastasize, cancerous cells loose their structure and constantly swing away from the mother's tumor tissue, Other parts of the body organs "home", the above process is called the epithelial cells to mesenchymal cells transdifferentiation process and the conversion of stromal cells to epithelial cells (EMT and MET).
The researchers found that during the development of tubules, ASPP2 protein can promote the occurrence of MET process and thus filter out the body's blood waste, and when ASPP2 protein is missing, it can promote EMT process, especially in the expression of common cancer genes RAS cells, the EMT process is particularly evident, which will trigger the transfer of cancer. Subsequently, researchers conducted experiments on mouse models and found that when the antigen-antibody-expressing cancer cells in the mouse body express a lower level of ASPP2, they can be largely transferred to the brain cells. If these antigen-antibody-expressing cancer cells express a sufficient amount of ASPP2 , Its ability to transfer will be significantly reduced.