美國Seracare熱滅活大腸桿菌O103:H8陽性對照

廣州健侖生物科技有限公司

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美國Seracare熱滅活大腸桿菌O103:H8陽性對照

我司還提供其它進口或國產試劑盒：登革熱、瘧疾、流感、A鏈球菌、合胞病毒、腮病毒、乙腦、寨卡、黃熱病、基孔肯雅熱、克錐蟲病、違禁品濫用、肺炎球菌、軍團菌、化妝品檢測、食品安全檢測等試劑盒以及日本生研細菌分型診斷血清、德國SiFin診斷血清、丹麥SSI診斷血清等產品。

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PARS可以同時定位DNA、RNA和蛋白，“但仍然受到抗體擴散能力的限制，”Gradinaru說。因此在使用這一技術時，使用納米抗體等較小的標記。另外，數據處理也是PARS面臨的一大挑戰。
日本RIKEN和東京大學的科學家們，將組織脫色與光切熒光顯微鏡結合起來，成像了多種器官乃至整個生物體，得到了極為詳細的內部圖像。這一成果發表在本期的Cell雜志上。
理解生命的運作方式是一直系統生物學的*夢想。將組織和生物體透明化然后進行單細胞分辨率的精確成像，將成為實現這一夢想的全新途徑。
研究人員在這項研究中采用了一種名為CUBIC（Clear, Unobstructed Brain Imaging Cocktails and Computational Analysis）的方法，他們之前曾用這個方法成像了整個大腦。大腦組織富含脂類比較容易透明化，但機體其他部分含有許多能夠吸收光的生色團（chromophore），比如血紅素heme。血紅素是血紅蛋白的重要組分，存在于機體的絕大多數組織，并且會阻斷光線。
研究人員在針對這個問題進行研究時，意外發現CUBIC試劑中的氨基醇能夠將血紅素從血紅蛋白中提取出來，由此顯著提高器官的透明度。
他們用這個方法處理小鼠的大腦、心臟、肺、腎臟、肝臟甚至整個幼鼠和成年小鼠，得到了異常透明的小鼠。在此基礎上的光切（light-sheet）熒光顯微成像，獲得了非常清晰的3D圖像。為了測試這個方法的實用性，研究人員比較了糖尿病和非糖尿病小鼠的胰腺，發現它們的胰島存在明顯的差異，胰島是胰腺生產胰島素的結構。
CUBIC需要用試劑固定組織，所以不能用于活體生物。不過，CUBIC可以幫助人們深入了解器官的3D結構，以及特定基因在不同組織中的表達，文章的*作者Kazuki Tainaka說。“我們的方法能得到幾乎全身透明的幼鼠和成年小鼠。通過這個技術人們能觀察到組織里的細胞網絡，這是生物學和醫學領域的一個基本挑戰。”
“CUBIC可以用于3D病理學研究、解剖學研究和整個生物體的免疫組化分析。舉例來說，可以用CUBIC在細胞水平上觀察胚胎的發育，或者癌癥和自身免疫疾病的發展。深入理解疾病的過程，有助于我們開發新的治療策略。在單細胞水平上的全身成像，有望實現系統生物學領域的*夢想，”這項研究的*Hiroki Ueda說。
研究團隊正在進一步改進顯微成像方法，以便快速成像成年小鼠的整個機體甚至人類大腦。他們希望通過這一技術，深入理解自身免疫疾病和精神疾病的機制。

美國Seracare

我司還提供其它進口或國產試劑盒：登革熱、瘧疾、流感、A鏈球菌、合胞病毒、腮病毒、乙腦、寨卡、黃熱病、基孔肯雅熱、克錐蟲病、違禁品濫用、肺炎球菌、軍團菌、食品安全、化妝品檢測、藥物濫用檢測等試劑盒以及日本生研細菌分型診斷血清、德國SiFin診斷血清、丹麥SSI診斷血清等產品。

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【公司名稱】 廣州健侖生物科技有限公司
【市場部】    楊永漢

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【騰訊  】 2042552662
【公司地址】 廣州清華科技園創新基地番禺石樓鎮創啟路63號二期2幢101-103室

PARS can position DNA, RNA and proteins simultaneously, "but is still limited by the ability of antibodies to proliferate," said Gradinaru. Therefore, in the use of this technology, it is best to use smaller labels such as Nanobodies. In addition, data processing is also a major challenge facing PARS.
Scientists at Japan's RIKEN and the University of Tokyo combined tissue decolorization with light-cut fluorescence microscopy to image a wide range of organs and even entire organisms and obtain extremely detailed internal images. This result is published in this issue of Cell magazine.
Understanding the way life works is the ultimate dream of systems biology. Transparency of tissues and organisms followed by precise imaging of single-cell resolution will be a new way to achieve this dream.
In this study, the researchers used a method called CUBIC (Clear, Unobstructed Brain Imaging Cocktails and Computational Analysis), which they had previously used to image the entire brain. Cerebral tissue is more lipid-rich and more transparent, but the rest of the body contains many chromophores that absorb light, such as heme. Heme is an important component of hemoglobin, exists in the vast majority of the body's tissues, and will block the light.
Researchers in the study of this issue, the accidental discovery of CUBIC reagent amino alcohol can hemoglobin extracted from hemoglobin, thereby significantly improving organ transparence.
Using this method, they treated the mouse's brain, heart, lungs, kidneys, liver, and even the entire young and adult mice to obtain abnormally transparent mice. On the basis of this light-sheet fluorescence microscopy, a very sharp 3D image was obtained. To test the usefulness of this method, the researchers compared the pancreata in diabetic and non-diabetic mice and found a clear difference in their islets, the structure of the pancreas that produces insulin.
CUBIC requires reagents to fix the tissue so it can not be used in living organisms. However, CUBIC can help people gain insight into the 3D structures of organs and the expression of specific genes in different tissues, said first author Kazuki Tainaka. "Our approach results in almost whole-body, transparent young and adult mice, through which one can observe the cellular networks in the tissue, which is a fundamental challenge in the biological and medical fields."
CUBIC can be used for 3D pathology, anatomy and immunohistochemistry of whole organisms, for example, CUBIC can be used to observe the development of embryos at the cellular level or the development of cancer and autoimmune diseases. The disease process helps us to develop new therapeutic strategies, and whole-body imaging at the single-cell level is expected to bring about the ultimate dream in the field of system biology, "said Hiroki Ueda, a research leader.
The research team is further improving the microscopic imaging method to quickly image the entire body of adult mice and even the human brain. They hope that through this technology, they will have a deep understanding of the mechanisms of autoimmune diseases and mental illnesses.