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美國NOVABIOS可替寧檢測試劑盒
廣州健侖生物科技?有限公司
本司長期供應尼古丁(可替寧)檢測試劑盒,其主要品牌包括美國NovaBios、廣州健侖、廣州創侖等進口產品,國產產品,試劑盒的實驗方法是膠體金方法。
我司還提供其它進口或國產試劑盒:登革熱、瘧疾、流感、A鏈球菌、合胞病毒、腮病毒、乙腦、寨卡、黃熱病、基孔肯雅熱、克錐蟲病、違禁品濫用、肺炎球菌、軍團菌等試劑盒以及日本生研細菌分型診斷血清、德國SiFin診斷血清、丹麥SSI診斷血清等產品。
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【包裝規格】
1人份/袋,40人份/盒
【預期用途】
尼古丁(Nicotine)是煙草中的主要生物堿,是導致吸煙成癮的物質動因,也是評價人體攝入煙草煙霧的常用指標。但因為尼古丁半衰期短,無法作為標志物檢測,其代謝物可替寧因為半衰期長作為吸煙和戒煙的標志物。
本品采用競爭抑制法和膠體金免疫層析技術,用于快速定性檢測人體唾液中的可替寧,適用于評價煙草煙霧攝入的初步篩查。
【主要組成成份】
【檢驗方法】
美國NOVABIOS可替寧檢測試劑盒
有研究結果顯示,細菌的主要有效成分——細菌大細菌(THC)主要作用于CB1受體。 細菌素不僅存在于能令人上癮的細菌中(植物性細菌素,THC),也自然地存在于動物神經和免疫系統里(內源性細菌素,N-花生四烯酸氨基乙醇和2-花生四烯酸甘油)。從中世紀開始,就有醫生已經認識到細菌具有治療效果。事實上,現代醫學也證明了細菌素對于治療多發性硬化癥和某些類型的疼痛有一定的效果。尚在研究階段的數據顯示,細菌素對某些癌癥和腦外傷造成的損害可能有一定的療效。而且,CB1特異性小分子拮抗劑在治療肥胖及相關并發癥、精神性疾病、肝纖維化和尼古丁成癮等方面顯示了不俗的效果。 2006年,*用于治療肥胖癥的CB1特異性拮抗劑利莫那班獲得歐洲醫學委員會(EMA)的上市批準。很快,美國FDA卻發現該藥物可能引發焦慮、抑郁、細菌傾向等精神方面的副作用,從而禁止。同時,歐洲也很快發現這種藥確實會引起抑郁、焦慮甚至細菌傾向,zui終只能將其撤下。 但是,由于缺乏對減肥藥利莫那班(Rimonabant, Sanofi-Aventis)與CB1相互作用分子層面的了解,至今人們對減輕CB1藥物副作用的努力收效甚微。“差不多5年前,人們還曾經認為CB1結構無法破解。”中國科學院上海藥物研究所研究員李揚在接受《中國科學報》記者采訪時提及。 “這是因為CB1蛋白的表達量比較低,穩定性差,很難獲得足夠穩定的蛋白樣品進行晶體學研究。”上海科技大學iHuman研究所副所長、教授、該項目負責人劉志杰在介紹CB1研究瓶頸時表示。 揭示CB1三維精細結構 面對重重困難,劉志杰課題組的研究人員嘗試了大量不同的表達載體改造策略,與學術機構以及藥企合作,對不同類型的配體小分子進行篩選和針對結晶學實驗設計穩定性更好、解離速率更慢的小分子。“我們對不同的表達系統及不同的細胞系都進行了嘗試,發現它們對晶體的生長和衍射質量影響很大,這一點在之前的GPCR結構研究中,沒有引起足夠的重視。”該論文的*作者華甜對《中國科學報》記者解釋道。 這項研究成功解析了CB1與小分子拮抗劑AM6538復合物的三維精細結構,分辨率達到2.8埃(10-10米)。特別重要的是,該晶體結構揭示了CB1結合AM6538的復雜疏水結合口袋(binding pocket)。
美國NOVABIOS可替寧檢測試劑盒
想了解更多的韓國SD產品及服務請掃描下方二維碼:我司還提供其它進口或國產試劑盒:登革熱、瘧疾、流感、A鏈球菌、合胞病毒、腮病毒、乙腦、寨卡、黃熱病、基孔肯雅熱、克錐蟲病、違禁品濫用、肺炎球菌、軍團菌等試劑盒以及日本生研細菌分型診斷血清、德國SiFin診斷血清、丹麥SSI診斷血清等產品。
二維碼掃一掃
【公司名稱】 廣州健侖生物科技有限公司
【】 楊永漢
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【騰訊 】
【公司地址】 廣州清華科技園創新基地番禺石樓鎮創啟路63號二期2幢101-3室
【企業文化宣傳】
Some studies have shown that the main bacterial component of bacteria - Bacteria (THC) mainly act on the CB1 receptor. Bacteriocins are found not only in addictive bacteria (plant bacteriocins, THC) but also naturally in the animal's nervous and immune system (endogenous bacteriocins, N-arachidonic acid aminoethanol and 2- Arachidonic acid glycerol). From the beginning of the Middle Ages, some doctors have realized that bacteria have a therapeutic effect. In fact, modern medicine has also demonstrated that bacteriocins have some effect on the treatment of multiple sclerosis and certain types of pain. Data still under study shows that bacteriocins may have some effect on some cancers and traumatic injuries. Moreover, CB1-specific small molecule antagonists have shown impressive results in the treatment of obesity and related complications, psychiatric disorders, liver fibrosis and nicotine addiction. In 2006, the first CB1 antagonist, rimonabant, used to treat obesity was marketed approved by the European Medical Commission (EMA). Soon, the United States FDA found that the drug may cause psychological side effects such as anxiety, depression, bacterial propensity, and thus banned. In the meantime, Europe soon discovered that the drug did cause depression, anxiety and even bacterial tendencies, eventually removing it. However, efforts to alleviate the side effects of CB1 have so far failed due to a lack of understanding of molecular aspects of the interaction of the bariatric drug Rimonabant (Sanofi-Aventis) with CB1. "Almost five years ago, people once thought CB1 could not be cracked," said Li Yang, a researcher at Shanghai Institute of Materia Medica, Chinese Academy of Sciences, in an interview with a reporter at China Science News. "This is because CB1 protein expression is low, poor stability, it is difficult to obtain sufficiently stable protein samples for crystallography." Shanghai University of Technology iHuman Institute Deputy Director, Professor Liu Zhijie, the project leader in introducing the CB1 study When the bottleneck said. To reveal the three-dimensional fine structure of CB1 faces many difficulties, Liu Zhijie's group of researchers tried a large number of different transformation strategies of expression vectors, with international academic institutions and pharmaceutical companies to screen different types of ligand small molecules and for crystallization experiments Design better stability, slower dissociation rate of small molecules. "We tried out different expression systems and different cell lines and found that they have a great influence on the crystal growth and diffraction quality, which did not get enough attention in previous GPCR structure studies." The first author, Hua Tian, ??explained to reporters in China Science News. This study successfully resolved the three-dimensional fine structure of CB1 with the small molecule antagonist AM6538 complex with a resolution of 2.8 angstroms (10-10 m). Of particular importance, this crystal structure reveals the complex hydrophobic binding pocket of CB1 binding AM6538.
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