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髓過氧化物酶抗中性粒細胞胞質(zhì)IgG抗體

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更新時間：2018-05-09 17:29:18瀏覽次數(shù)：523次

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商鋪產(chǎn)品：9811條

所在地區(qū)：上海上海

聯(lián)系人：馬經(jīng)理 （銷售專員）

產(chǎn)品簡介

髓過氧化物酶抗中性粒細胞胞質(zhì)IgG抗體產(chǎn)品介紹：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

詳細介紹

英文名稱Myeloperoxidase
中文名稱髓過氧化物酶抗中性粒細胞胞質(zhì)IgG抗體
別    名Myeloperoxidase; MPO; c-ANCA; 89 kDa myeloperoxidase; 84 kDa yeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain; EC 1.11.1.7; PERM_HUMAN.
說 明 書0.1ml  0.2ml  
研究領(lǐng)域腫瘤  細胞生物  免疫學  激酶和磷酸酶  淋巴細胞  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Guinea Pig, 
產(chǎn)品應(yīng)用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量77kDa
細胞定位細胞漿 
性    狀Lyophilized or Liquid
濃    度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Myeloperoxidase
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
產(chǎn)品介紹background:
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq, Jul 2008].

Function:
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.

Subunit:
Tetramer of two light chains and two heavy chains.

Subcellular Location:
Lysosome.


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