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FITC標(biāo)記的激活素受體相互作用蛋白1抗體

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更新時間:2018-06-07 12:53:22瀏覽次數(shù):392次

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所在地區(qū):上海上海

聯(lián)系人:馬經(jīng)理 (銷售專員)

產(chǎn)品簡介

FITC標(biāo)記的激活素受體相互作用蛋白1抗體產(chǎn)品介紹:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

詳細(xì)介紹

英文名稱Anti-AIP1/FITC
中文名稱FITC標(biāo)記的激活素受體相互作用蛋白1抗體
別    名Activin receptor interacting protein 1; Acvri1; Acvrinp1; ACVRIP1; AIP1; AIP 1; Aip-1; ARIP1; Atrophin 1 interacting protein 1; Atrophin 1 interacting protein A; Atrophin-1-interacting protein 1; Atrophin-1-interacting protein A; MAGI-2; MAGI2; MAGI2_HUMAN; Membrane associated guanylate kinase 2; Membrane associated guanylate kinase inverted 2; Membrane associated guanylate kinase WW and PDZ domain containing 2; Membrane associated guanylate kinase WW and PDZ domain containing protein 2; Membrane-associated guanylate kinase; Membrane-associated guanylate kinase inverted 2; S SCAM; SSCAM; WW and PDZ domain-containing protein 2.
說 明 書100ul  
研究領(lǐng)域細(xì)胞生物  神經(jīng)生物學(xué)  細(xì)胞膜受體  細(xì)胞膜蛋白  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat, Dog, Cow, Sheep, 
產(chǎn)品應(yīng)用ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量159kDa
細(xì)胞定位細(xì)胞膜 
性    狀Lyophilized or Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human AIP1 (301-380aa)
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹background:
AIP1 (ASK-interacting protein 1), also known as DAB2IP (DAB2 interacting protein), is a 1,189 amino acid protein that localizes to both the membrane and the cytoplasm and contains one Ras-GAP domain, one PH domain and one C2 domain. Expressed at low levels in prostate tissue, AIP1 functions as a Ras GTPase-activating protein that interacts with ASK 1 and, via this interaction, disrupts the association of ASK 1 with an inhibitory 14-3-3 complex, thereby allowing free ASK 1 to function within the cell. AIP1 exists as multiple alternatively spliced isoforms and is down-regulated in prostate cancer tissue, suggesting a role in tumor suppression. Chromosomal aberrations in the gene encoding AIP1 are associated with acute myeloid leukemia (AML), implicating a role for AIP1 fusion proteins in tumorigenesis.

Function:
Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation.


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