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當(dāng)前位置：上海泛柯實業(yè)有限公司>>抗體>>一抗>>FITC標記的抑制蛋白結(jié)構(gòu)域蛋白4抗體

FITC標記的抑制蛋白結(jié)構(gòu)域蛋白4抗體

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更新時間：2015-05-07 15:04:09瀏覽次數(shù)：287次

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商鋪產(chǎn)品：9811條

所在地區(qū)：上海上海

聯(lián)系人：馬經(jīng)理 （銷售專員）

產(chǎn)品簡介

FITC標記的抑制蛋白結(jié)構(gòu)域蛋白4抗體產(chǎn)品介紹：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

詳細介紹

英文名稱Anti-ARRDC4/FITC
中文名稱FITC標記的抑制蛋白結(jié)構(gòu)域蛋白4抗體
別    名ARRDC 4; Arrestin domain containing protein 4; ARRD4_HUMAN.
說 明 書100ul  
研究領(lǐng)域細胞生物  免疫學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat, Chicken, Pig, Cow, Sheep, 
產(chǎn)品應(yīng)用IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量45 kDa
性    狀Lyophilized or Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ARRDC4
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹background:
ARRDC4 belongs to the arrestin family. The arrestins are a family of proteins that are important for regulating signal transduction within cells. Arrestins are part of a conserved two step mechanism for regulating the activity of G-protein coupled receptors (GPCRs). In response to a stimulus, GPCRs activate a heterotrimeric G protein. In order to turn off this response, or adapt to a constant stimulus, activated receptors need to be silenced. The first step is phosphorylation by a class of serine/threonine kinases called G protein coupled receptor kinases (GRKs). This phosphorylation specifically marks the activated receptor for arrestin binding. Once arrestin is bound to the receptor it is unable to signal further. Recent research continues to expand the known actions of arrestins, which can bind to other classes of receptors and can directly activate signaling pathways on their own. Different arrestins (visual arrestin (or Arrestin 1), beta-arrestin 1 (or Arrestin 2) and beta-arrestin 2 (or Arrestin 3) can reduce the activity of their target GPCRs in several different ways.

Similarity:
Belongs to the arrestin family.

Database links:
UniProtKB/Swiss-Prot: Q8NCT1.3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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