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聯(lián)系我時,請告知來自 智慧城市網(wǎng)FITC標記的蛋白激酶A錨定蛋白6抗體產(chǎn)品介紹:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
英文名稱 | Anti-AKAP6/FITC |
中文名稱 | FITC標記的蛋白激酶A錨定蛋白6抗體 |
別 名 | A kinase (PRKA) anchor protein 6; A kinase anchor protein 100; A kinase anchor protein 100 kDa; A kinase anchor protein 6; ADAP 100; ADAP 6; ADAP100; ADAP6; AKAP 100; AKAP 6; AKAP100; Human A kinase anchor protein AKAP100; KIAA0311; mAKAP; PRKA 6; PRKA6; Protein kinase A anchoring protein 6; AKAP6_HUMAN. |
說 明 書 | 100ul |
研究領(lǐng)域 | 細胞生物 信號轉(zhuǎn)導 細胞周期蛋白 激酶和磷酸酶 |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | Human, Mouse, Rat, Cow, Horse, Rabbit, |
產(chǎn)品應(yīng)用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 257kDa |
細胞定位 | 細胞膜 |
性 狀 | Lyophilized or Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human AKAP6 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
儲 存 液 | Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 |
保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 | background: The A Kinase Anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. AKAP6 is a member of the AKAP family. It is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum. Function: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes. Subunit: Interacts with RII subunit of PKA, phosphatase 2B (calcineurin) and AKAP79. Subcellular Location: Sarcoplasmic reticulum. Nucleus membrane. Note=In heart muscle. Participation of multiple targeting signals allow correct intracellular targeting. These may be repeated motifs rich in basic and hydrophobic amino acids, palmitoylated/myristoylated motifs or alternatively splice targeting sequences. Tissue Specificity: Highly expressed in cardiac and skeletal muscle, followed by brain. Similarity: Contains 2 spectrin repeats. Database links: UniProtKB/Swiss-Prot: Q13023.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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