| 英文名稱 | Anti-AUP1/FITC |
| 中文名稱 | FITC標記的原始廣泛存在蛋白1抗體 |
| 別 名 | AA589454; AUP 1; AUP1; AUP1_HUMAN; Ancient ubiquitous protein 1. |
| 說 明 書 | 100ul |
| 研究領域 | 心血管 細胞生物 細胞周期蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, |
| 產品應用 | IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 53kDa |
| 細胞定位 | 細胞膜 |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human AUP1/Ancient ubiquitous protein 1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產品介紹 | background:
Ancient ubiquitous protein 1 (AUP1) contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. It has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits.
Function:
May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome.
Subunit:
Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with the cytoplasmic tail of ITGA2B, ITGA1, ITGA2, ITGA5, ITGAV and ITGAM.
Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type III membrane protein; Cytoplasmic side.
Tissue Specificity:
Detected in blood plaets and leukocytes (at protein level). Ubiquitous. Highly expressed in placenta, liver, kidney, skeletal muscle, heart and brain.
Similarity:
Belongs to the AUP1 family.
Contains 1 CUE domain.
Database links:
UniProtKB/Swiss-Prot: Q9Y679.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
