產(chǎn)品名稱：DULLARD蛋白抗體

別名：Dullard homolog; HSA 011916; NET 56 antibodySerine threonine protein phosphatase dullard; CNEP1_HUMAN.  

濃度：1mg/1ml

規(guī)格：0.2ml/200μg          

抗體來源：Rabbit  

克隆類型：polyclonal

交叉反應：Human, Mouse, Rat, Dog, Cow, Horse   

產(chǎn)品類型：DULLARD蛋白抗體一抗    

研究領域：神經(jīng)生物學 信號轉(zhuǎn)導 激酶和磷酸酶 表觀遺傳學  

蛋白分子量：predicted molecular weight: 28kDa

性狀：Lyophilized or Liquid

免疫原：KLH conjugated synthetic peptide derived from human DULLARD

亞型：IgG

純化方法：affinity purified by Protein A

儲存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

產(chǎn)品應用：WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500
（石蠟切片需做抗原修復）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user.  

保存條件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

產(chǎn)品介紹：In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. Dullard, also known as NET56, is a 244 amino acid single-pass membrane protein that localizes to both the nucleus and the endoplasmic reticulum and contains one FCP1 homology domain. Functioning as a serine/threonine phosphatase, Dullard catalyses the dephosphorylation of target proteins and is thought to be required for proper nuclear membrane morphology. Human Dullard shares 92% sequence identity with its zebrafish counterpart, suggesting a conserved role between species.

Function : DULLARD is a serine/threonine phosphatase which may be required for proper nuclear membrane morphology. It is involved in LPIN1 dephosphorylation and may antagonize BMP signaling.

Subunit : Interacts with CNEP1R1; the complex dephosphorylates LPIN1 and LPIN2.

Subcellular Location : Endoplasmic reticulum membrane; Single-pass membrane protein. Nuclear membrane; Single-pass membrane protein.

Tissue Specificity : Muscle specific with lower expression in other metabolic tissues.

Similarity : Belongs to the dullard family.

Contains 1 FCP1 homology domain.

Database links : UniProtKB/Swiss-Prot: O95476.2