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閱讀:269發(fā)布時(shí)間:2014-7-10
Anti-Vimentin抗體,波形蛋白抗體相關(guān)產(chǎn)品:
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Anti-E Tag 抗E Tag抗體
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Anti-CNR-1(Cannabinoid receptor I brain) 鈣粘蛋白相關(guān)的神經(jīng)受體1抗體
Anti-CNTFR α(Ciliary neurotrophic factor receptor alpha) 抗睫狀神經(jīng)營(yíng)養(yǎng)因子受體α抗體
Anti-CNR-2/PCDHA 6(Cadherin-related neuronal receptor2) 鈣粘蛋白相關(guān)的神經(jīng)受體2抗體
Anti-Vimentin抗體,波形蛋白抗體Background: Vimentin is the major subunit protein of the intermediate filaments of mesenchymal cells. It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain-dependent contractile event. This results in cytoskeletal changes that facilitate the interaction of the lipid droplets within mitochondria, and subsequent transport of cholesterol to the organelles leading to an increase in steroid synthesis. Immunohistochemical staining for Vimentin is characteristic of sarcomas (of neural, muscle and fibroblast origin) compared with carcinomas which are generally negative. Melanomas, lymphomas and vascular tumors may all stain for Vimentin. Vimentin antibodies are thus of value in the differential diagnosis of undifferentiated neoplasms and malignant tumors. They are generally used with a panel of other antibodies including those recognizing cytokeratins, lymphoid markers, S100, desmin and neurofilaments.
Anti-Vimentin抗體,波形蛋白抗體Application :
Western blotting 1:100-500
Immunohistochemistry 1:100-500
IF=1:100-500
ELISA 1:500-1000
IP=1:20-100
IHC-P=1:100-500 IHC-F=1:100-500
Optimal working dilutions must be determined by the end user.
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主營(yíng)產(chǎn)品:ELISA試劑盒,科研抗體,細(xì)胞株細(xì)胞系,生物試劑,培養(yǎng)基,動(dòng)物血清
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